Synthesis, Morphostructure, Surface Chemistry and Preclinical Studies of Nanoporous Rice Husk-Derived Biochars for Gastrointestinal Detoxification

J.M. Jandosov, L.I. Mikhalovska, C.A. Howell, D.I. Chenchik, B.K. Kosher, S.B. Lyubchik, J. Silvestre-Albero, N.T. Ablaikhanova, G.T. Srailova, S.T. Tuleukhanov, S.V. Mikhalovsky

Abstract


This article summarizes the methodology of synthesis, surface functionalization and structural properties of rice husk-derived nanostructured carbon enterosorbents (biochars) in connection with the preliminary in vitro study results of uraemic toxin adsorption in model experiments, as well as preclinical trials in vivo. The obtained nanostructured carbon sorbents were studied using a number of modern physicochemical methods of investigation: low-temperature nitrogen adsorption, isotherms recording and calculation of the specific surface area, pore volumes were carried out using the Autosorb-1 "Quantachrome" device. Scanning electron microscopy and EDS-analysis. Mercury intrusion porosimetry analysis of the ACs were accomplished using "Quantachrome Poremaster" data analysis software. In vitro adsorption results assessed by use of HPLC and UV-spectroscopy for the nanostructured carbon sorbents with respect to the investigated low-molecule toxins suggest that the rice husks-derived carbon enterosorbents modified with the functional groups are able to reduce clinically significant levels of uraemic toxins and are comparable to the commercial enterosorbents. Based on the results of the comparative analysis for biocompatibility of canine kidney epithelial cells it was determined that the samples of the modified sorbents CRH P 450 and CRH 475 KOH 850 N do not exhibit cytotoxicity in comparison with the commercial carbon enterosorbent «Adsorbix Extra». According to the results of the in vivo studies, it was determined that there was a the positive effect of enterosorbent on uremia and intoxication.


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References


  1. Yupeng Guo, Kaifeng Yu, Zichen Wang, Hongding Xu, Carbon 41 (8) (2003) 1645–1687. Crossref
  2. V.A. Yakovlev, P.M. Yeletsky, M.Yu. Lebedev, D.Yu. Ermakov, V.N. Parmon, Chem. Eng. J. 134 (2007) 246–255. Crossref
  3. Z.R. Ismagilov, N.V. Shikina, I.P. Andrievskaya, N.A. Rudina, Z.A. Mansurov, M.M. Burkitbaev, M.A. Biisenbaev, A.A. Kurmanbekov, Catal. Today 147 (2009) 58‒65. Crossref
  4. M. Ahiduzzaman, A. K.M. Sadrul Islam, American Journal of Physical Chemistry 5 (2016) 94‒98. Crossref
  5. World Health Organization: 2012–2016 Action Plan for the Global Strategy for the Prevention and Control of Noncommunicable Diseases: Prevent and Control Cardiovascular Diseases, Cancer, Chronic Respiratory Diseases.
  6. G. Glorieux, R. Vanholder, Contrib. Nephrol. 168 (2011) 117–128. Crossref
  7. S. Yamamoto, J.J. Kazama, T. Wakamatsu, Y. Takahashi, Y. Kaneko, S. Goto, I. Narita, Renal Replacement Therapy 2 (2016) 43. Crossref
  8. J.M. Jandosov, Z.A. Mansurov, M.A. Biisenbayev, A.R. Kerimkulova, Z.R. Ismagilov, N.V. Shikina, I.Z. Ismagilov, I.P. Andrievskaya, Eurasian Chemico-Technological Journal 13 (2011) 105‒113. Crossref
  9. J.M. Jandosov, Z.A. Mansurov, M.A. Bijsenbayev, M.I. Tulepov, Z.R. Ismagilov, N.V. Shikina, I.Z. Ismagilov, I.P. Andrievskaya Advanced Materials Research 602–604 (2013) 85–89. Crossref
  10. S.J. Gregg, K.S.W. Sing, Adsorption, Surface Area and Porosity, London: Academic Press. 1982.
  11. J.M. Jandosov, Z.A. Mansurov, A.Zh. Baimenov, A.T. Orazbekov, C.A. Howell, S.V. Mikhalovsky, S.R. Sandeman. Elimination of Uraemic Toxins and Inflammatory Cytokines from Human Plasma by Biomass-derived Carbon Adsorbents. The Annual World Conference on Carbon. – Jeju, Korea, 2014. – ID 423.
  12. L.S. Fira, I.N. Klisch, O.M. Oleshchuk, P.G. Likhatsky. A study of the effectiveness of enterosgel in experimental renal failure, Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kiev, 2010 (in Russian).
  13. P.M. Eletskii, V.A. Yakovlev, V.B. Fenelonov, V.N. Parmon, Kinet. Catal. 49 (2008) 708–719. Crossref
  14. J.M. Jandosov, Z.A. Mansurov, A.Zh. Baimenov, C.A. Howell, S.V. Mikhalovsky, S.R. Tennison, O.P. Kozynchenko, A.T. Orazbekov, Honeycomb Carbon Monoliths from Renewable Materials for Removal of Inflammatory Cytokines from Human Plasma, The Annual World Conference on Carbon, Dresden, Germany, 2015.
  15. M. Jagtoyen, F. Derbyshire, Carbon 31 (1993) 1185‒1192. Crossref
  16. R.U. Khabriev. Manual on experimental preclinical study of new pharmacological substances, Moscow: Medicine, 2005, 832 p. (in Russian). ISBN: 5-225-04219-8




DOI: https://doi.org/10.18321/ectj678

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