Purpurin Esters Containing a Saturated Cyclic Fragment with Antimicrobial Activity

  • Т. V. Kharlamova JSC “Institute of Chemical Sciences named after A.B. Becturov”, 106 Ualikhanov str., 050010, Almaty, Kazakhstan
  • R. B. Seidakhmetova JSC “Institute of Chemical Sciences named after A.B. Becturov”, 106 Ualikhanov str., 050010, Almaty, Kazakhstan
  • K. D. Praliyev JSC “Institute of Chemical Sciences named after A.B. Becturov”, 106 Ualikhanov str., 050010, Almaty, Kazakhstan
Keywords: purpurin, acid chlorides of saturated, cyclic carboxylic acids, antimicrobial activity

Abstract

 The present study is a continuation of the scientific research works for the synthesis of anthraquinonе-containing derivatives with cyclic ring systems by the interaction of 1,2,4-trihydroxyanthraquinone (purpurin) with cyclic carboxylic acid chlorides. Series of purpurin esters containing a saturated cyclic fragment was studied for antibacterial activity about museum strains of microorganisms. The effects of these preparations in vitro about Staphylococcus aureus ATCC 6538, Bacillus subtilis ATCC 6633, Escherichia coli ATCC 25922, Pseudomonas aeruginosa АТСС 27853 and fungus Сandida albicans АТСС 10231 were studied. It has been found that the compounds with the cyclohexane fragment have possess an antimicrobial activity with strains of microorganisms Staphylococcus aureus АТСС 6538 for which the MIC value was 31.25 μg/ml.

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Published
2020-03-26
How to Cite
[1]
KharlamovaТ., R. Seidakhmetova, and K. Praliyev, “Purpurin Esters Containing a Saturated Cyclic Fragment with Antimicrobial Activity”, Eurasian Chem. Tech. J., vol. 22, no. 1, pp. 43-49, Mar. 2020.
Section
Articles

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