@article{Issayeva_Akhmetova_Datkhayev_Omyrzakov_Praliyev_Ross_2019, title={The Search for Biologically Active Compounds in the Series of N-ethoxyethylpiperidine Derivatives}, volume={21}, url={https://ect-journal.kz/index.php/ectj/article/view/822}, DOI={10.18321/ectj822}, abstractNote={<p>With the aim to introduce fragment of cyclopropane and fragments of <em>p-, m-, o</em>-fluorophenyls into the structures of N-ethoxyethylpiperidines, acylation of oxime and phenylacetylenic alcohol of 1-(2-ethoxyethyl)-4-ketopiperidine by cyclopropanecarbonylchloride was carried out; on the basis of 1-(2-ethoxyethyl)-4-ethynyl-4-hydroxypiperidine (cascaine alcohol), acylation by 4-fluoro-, 3-fluoro-, 2-fluorobenzoylchlorides was carried out with formation of the corresponding piperidine containing hydrochlorides of cyclopropanecarboxylic acid esters and para-, meta-, ortho-fluorobenzoic esters. Acylation reaction on the hydroxyl group of compounds is carried out in absolute dioxane, the acylating agents are cyclopropanecarbonylchloride, <em>p-, m-, o</em>-fluorobenzoyl chlorides taken in excess. The obtained esters of cyclopropanecarboxylic and para-, meta-, ortho-fluorobenzoic acids are crystalline substances with a clear melting point, well soluble in water, ethanol, acetone. <em>P</em>-fluorobenzoates are obtained with better yields, m-fluorobenzoates occupy an intermediate position, and o-fluorobenzoates are formed with the lowest yields. The best yields of fluorobenzoates are obtained using dioxane as a solvent. Para-, meta-, ortho-fluorobenzoic esters of 1-(2-ethoxyethyl)-4-ethynyl-4-hydroxypiperidine coded A-4 โ€“ A-6 were studied for the presence of antimicrobial activity, the actions of these preparations were evaluated <em>in vitro </em>in relation to strains of gram-positive bacteria <em>Staphylococcus aureus</em>, <em>Bacillus subtilis</em>, gram-negative strains of <em>Escheri</em><em>ั</em><em>hia coli</em>, <em>Pseudomonas aeruginosa </em>and to yeast fungus <em>ะก</em><em>andida albicans </em>by the diffusion method into agar (holes). Introduction of fluorine atom into the structure of cascaine lead to manifestation of antimicrobial activity.</p>}, number={2}, journal={Eurasian Chemico-Technological Journal}, author={Issayeva, U. B. and Akhmetova, G. S. and Datkhayev, U. M. and Omyrzakov, M. T. and Praliyev, K. D. and Ross, S. A.}, year={2019}, month={Jun.}, pages={125โ€“133} }