TY - JOUR AU - Koshetova, Zh.A. AU - Yu, V.K. AU - Iskakova, T.K. AU - Zhumanova, N.A. AU - Beketov, K.M. AU - Malmakova, A.E. AU - Praliyev, K.D. AU - Seilkhanov, T.M. AU - Berlin, K.D. PY - 2022/03/31 Y2 - 2024/03/28 TI - Novel 7-Aryliden-3,3a,4,5,6,7-(hexahydro-5-(2-ethoxyethyl)-2-phenyl- 3-aryl-2H-pyrazolo[4,3-c]pyridine Hydrochloride: Synthesis and Structure JF - Eurasian Chemico-Technological Journal JA - Eurasian Chem.-Technol. J. VL - 24 IS - 1 SE - Articles DO - 10.18321/ectj1147 UR - https://ect-journal.kz/index.php/ectj/article/view/1147 SP - 43-50 AB - <p>A Claisen-Schmidt type reaction of 1-(2-ethoxyethyl)piperidin-4-one with differ­ent aromatic aldehydes led to corresponding dienones with a yield of 65‒71%. 7-Arylidene-3,3a,4,5,6,7-(hexahydro-5-(2-ethoxyethyl)-2-phenyl-3-aryl-2<em>H</em>-pyrazolo[4,3-<em>c</em>]pyridines were synthesized by heterocyclization of 3,5-dia­rylidene-piperidin-4-ones with phenylhydrazine hydrochloride in methanol at 70 °C over 4‒6 h. The X-ray crystal structure determination of 7-(<em>p</em>-methoxy­benzyliden)-3,3a,4,5,6,7-(hexahydro-5-(2-ethoxyethyl)-2-phenyl-3-(<em>p</em>-methoxy­phenyl)-2<em>H</em>-pyrazolo[4,3-<em>c</em>]pyridine hydrochloride (the deposition number is CCDC 862410) was completed. The piperidine and pyrazoline rings are close to a chair and envelope conformations, respectively.</p><p>&nbsp;</p> ER -