TY - JOUR AU - Kharlamova, Т. V. AU - Gabdrakipov, A. V. AU - Seidakhmetova, P. B. AU - Praliyev, K. D. PY - 2020/09/30 Y2 - 2024/03/29 TI - Antibacterial Activity of Synthesized Derivatives of Purpurin Containing Cyсlopropane and Cyclobutane Fragment JF - Eurasian Chemico-Technological Journal JA - Eurasian Chem.-Technol. J. VL - 22 IS - 3 SE - Articles DO - 10.18321/ectj972 UR - https://ect-journal.kz/index.php/ectj/article/view/972 SP - 213-218 AB - <p>The present study is a continuation of the scientific research works for the synthesis of anthraquinonе-containing derivatives with cyclic ring systems by the interaction of 1,2,4-trihydroxyanthraquinone (purpurin) with cyclopropanecarboxylic acid chloride and cyclobutanecarboxylic acid chloride by using the ultrasonic treatment. Esters of purpurin, studied for antibacterial activity in museum test strains of microorganisms (<em>Staphylococcus aureus </em>ATCC 6538-P, <em>Bacillus subtilis </em>ATCC 6633, <em>Escherichia coli </em>ATCC 25922, <em>Pseudomonas aeruginosa </em>АТСС 27853, <em>С</em><em>andida albicans </em>АТСС 10231) in vitro with the determination of the minimum inhibitory concentration (MIC) value. The study revealed that the cyclopropane substituent exhibits moderate antibacterial activity against <em>Bacillus subtilis </em>ATCC 6633. While with the cyclobutane moiety it had a weak effect with respect to <em>Pseudomonas aeruginosa </em>ATCC strain. It has been found that the compounds with the cyclopropane and cyclobutane fragment have possessed antimicrobial activity in relation to strains of microorganisms <em>Staphylococcus aureus </em>АТСС 6538 for which the MIC value was 62.5 μg/ml.</p> ER -