Composite Medicine “Azisal” Based on Azithromycin and Salicylic Acid
DOI:
https://doi.org/10.18321/ectj229Abstract
Salicylic acid essentially is obtained under the pressure by the method of Kolbe-Schmidt. One of the biggest
drawbacks of this method is the necessity of synthesizing sodium phenolate in advance which involves
considerable technological difficulties: water predistillation under vacuum and also the dry sodium phenolate
getting very hygroscopic. It is therefore of interest to look for more convenient alternative pathways
for the synthesis of salicylic acid, excluding the use of sodium phenolate and this drawback is eliminated
by using sodium and potassium salts of ethyl carbonic acid as carboxylation body. Consequently, according
to the more convenient method we obtained the salicylic acid. In medicine, 1% solution of salicylic acid
in 70 % alcohol called salicylic alcohol is used as an antiseptic. We investigated the antimicrobial activity
of a 1% solution of salicylic acid in various concentrations of ethanol (40%, 50%, 60%, 70%, 80% and
90%) in order to determine the effect of different concentrations of ethanol on the antimicrobial activity of
salicylic acid. The experiment proved that 1% solution of salicylic acid in various concentrations of ethanol
(40-90%) to the appropriate strains of bacteria acts with the same activity regardless of the concentration of
ethanol (40%, 50%, 60%, 70%, 80% and 90%). These actions of the acid are due to its solubility in alcohols
of different concentrations and complete disintegration of salicylic acid molecules into ions. Thus, on the
basis of antimicrobial research the necessity of preparation of 1% solution of salicylic acid in 40% alcohol
is proved as the drug is cheaper and cost-effective to produce. The technology of the new composition of
the drug “Azisal” consisting of 0.25 g azithromycin and 1.0 g salicylic acid in 60% ethanol was developed,
in a similar way solution of azithromycin in different concentrations 0.25, 0.5, 0.75, 1.0% in 60% ethanol
were prepared and their antimicrobial activities were defined. The comparison of their antimicrobial activity
shows the effectiveness of the composite product called “Azisal”.
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