Immobilization of Analgetic AB-101 into Calcium Alginate Gels

Authors

  • R.M. Iskakov A.B. Bekturov’s Institute of Chemical Science, 106 Walikhanov Street, 480100 Almaty, Kazakhstan
  • E.O. Batyrbekov A.B. Bekturov’s Institute of Chemical Science, 106 Walikhanov Street, 480100 Almaty, Kazakhstan
  • B.A. Zhubanov A.B. Bekturov’s Institute of Chemical Science, 106 Walikhanov Street, 480100 Almaty, Kazakhstan
  • Y.Y. Fomicheva A.B. Bekturov’s Institute of Chemical Science, 106 Walikhanov Street, 480100 Almaty, Kazakhstan
  • V. K. Yu A.B. Bekturov’s Institute of Chemical Science, 106 Walikhanov Street, 480100 Almaty, Kazakhstan
  • K.D. Praliev A.B. Bekturov’s Institute of Chemical Science, 106 Walikhanov Street, 480100 Almaty, Kazakhstan
  • D.K. Berlin Oklahoma State University, 107, Physical Sciences, Stillwater, 74078, Oklahoma, USA

DOI:

https://doi.org/10.18321/ectj547

Abstract

A new analgetic drug AB-101 has been immobilized into Ca2+-alginate gel beads with average diameter of 1 mm. A series of the alginate gel contains with various mannuronic/guluronic (M/G) ratios has been chosen to control the diffusion of the drug. Release of the drug from the alginate gel beads into physiological solutions consisting of sodium ions has been examined. A discontinuous time of the Fickian diffusion of the drug depending on M/G ratio was followed by a burst release of the remaining drugs. The burst release was due to a swift disintegration of Ca2+-alginate with exchange on sodium ions. The preceding discontinuous lag time promotes a free dissociate exchange of sodium-calcium ions in M units, while the burst disintegration leads to fast dissociation of G units. The lag time can be control by M/G ratio of Ca2+-alginate gels. The lag time increases if a content of the M units decreases. The increase of M units was led to more extensive swelling of the gel beads. Such way could be promising for a controlled drug delivery or the use in implants with controlled drug effect.

References

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Published

2002-10-20

How to Cite

Iskakov, R., Batyrbekov, E., Zhubanov, B., Fomicheva, Y., Yu, V. K., Praliev, K., & Berlin, D. (2002). Immobilization of Analgetic AB-101 into Calcium Alginate Gels. Eurasian Chemico-Technological Journal, 4(4), 293–295. https://doi.org/10.18321/ectj547

Issue

Vol. 4 No. 4 (2002)

Section

Articles

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