The Synthesis and in vitro Study of 9-fluorenylmethoxycarbonyl Protected Non-Protein Amino Acids Antimicrobial Activity

Authors

  • T.H. Sargsyan Scientific and Production Center “Armbiotechnology” NAS RA, 14 Gyurjyan, 0056, Yerevan, Armenia; Yerevan State University, Institute of Pharmacy, 1 A. Manoogian str., 0025 Yerevan, Armenia
  • L.A. Stepanyan Scientific and Production Center “Armbiotechnology” NAS RA, 14 Gyurjyan, 0056, Yerevan, Armenia
  • M.H. Israyelyan Scientific and Production Center “Armbiotechnology” NAS RA, 14 Gyurjyan, 0056, Yerevan, Armenia
  • H.I. Hakobyan Scientific and Production Center “Armbiotechnology” NAS RA, 14 Gyurjyan, 0056, Yerevan, Armenia
  • S.M. Jamgaryan Scientific and Production Center “Armbiotechnology” NAS RA, 14 Gyurjyan, 0056, Yerevan, Armenia
  • A.A. Gasparyan Scientific and Production Center “Armbiotechnology” NAS RA, 14 Gyurjyan, 0056, Yerevan, Armenia
  • A.S. Saghyan Scientific and Production Center “Armbiotechnology” NAS RA, 14 Gyurjyan, 0056, Yerevan, Armenia; Yerevan State University, Institute of Pharmacy, 1 A. Manoogian str., 0025 Yerevan, Armenia

DOI:

https://doi.org/10.18321/ectj1546

Keywords:

protecting group , peptide synthesis , non-protein amino acid , antimicrobial activity

Abstract

Using the 9-fluorenylmethoxycarbonyl protecting group, 9-fluorenylme­thoxycarbonyl-(S)-β-(N-imidazolyl)-α-alanine protected non-protein amino acid, not described in the literature, were developed. Then 9-fluorenyl­methoxycarbonyl-(S)-α-methylphenylalanine, 9-fluorenylmethoxycarbon­yl-(S)-α-allylglycine, 9-fluorenylmethoxycarbonyl-(S)-α-propargylglycine were synthesized by the same method. It was shown, that the 9-fluorenyl­methoxycarbonyl-(S)-β-(N-imidazolyl)-α-alanine (3) inhibited the growth of Gram-negative Salmonella tуphimurium G-38 and 9-fluorenyl-methoxycar­bonyl-(S)-α-methyl-phenylalanine (4) inhibited the growth Gram-positive Bacillus subtilis 17-89 bacteria.

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Published

2024-02-15

How to Cite

Sargsyan, T., Stepanyan, L., Israyelyan, M., Hakobyan, H., Jamgaryan, S., Gasparyan, A., & Saghyan, A. (2024). The Synthesis and in vitro Study of 9-fluorenylmethoxycarbonyl Protected Non-Protein Amino Acids Antimicrobial Activity . Eurasian Chemico-Technological Journal, 25(4), 235–240. https://doi.org/10.18321/ectj1546

Issue

Vol. 25 No. 4 (2023)

Section

Articles

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