The Synthesis and in vitro Study of 9-fluorenylmethoxycarbonyl Protected Non-Protein Amino Acids Antimicrobial Activity
DOI:
https://doi.org/10.18321/ectj1546Keywords:
protecting group , peptide synthesis , non-protein amino acid , antimicrobial activityAbstract
Using the 9-fluorenylmethoxycarbonyl protecting group, 9-fluorenylmethoxycarbonyl-(S)-β-(N-imidazolyl)-α-alanine protected non-protein amino acid, not described in the literature, were developed. Then 9-fluorenylmethoxycarbonyl-(S)-α-methylphenylalanine, 9-fluorenylmethoxycarbonyl-(S)-α-allylglycine, 9-fluorenylmethoxycarbonyl-(S)-α-propargylglycine were synthesized by the same method. It was shown, that the 9-fluorenylmethoxycarbonyl-(S)-β-(N-imidazolyl)-α-alanine (3) inhibited the growth of Gram-negative Salmonella tуphimurium G-38 and 9-fluorenyl-methoxycarbonyl-(S)-α-methyl-phenylalanine (4) inhibited the growth Gram-positive Bacillus subtilis 17-89 bacteria.
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