Investigating the Unexpected Behavior for the Release Kinetics of Brilliant Blue Encapsulated into Calcium Alginate Beads

Authors

  • M. M. Elnashar Department of Polymers and Pigments, Laboratory of Advanced Materials & Nanotechnology, Egypt
  • M. A. Yassin Department of Packing and Packaging Materials, National Research Centre, El-Behooth St., Cairo, Egypt
  • A. El-Fetouh Abdel Moneim Department of Packing and Packaging Materials, National Research Centre, El-Behooth St., Cairo, Egypt
  • E. M. Abdel Bary Polymer Laboratory, Chemistry Dep artment, Faculty of Science, Mansoura Univ ersity, ET-35516 Mansoura, Egypt

DOI:

https://doi.org/10.18321/ectj209

Abstract

This work is focused on investigating the unexpected behavior for the release kinetics of brilliant blue (BB) encapsulated into calcium alginate beads. By increasing the alginate concentration from 1-3% (w/v), the release of BB over time was found to follow two different behaviors. For the first two hours, the order was 1% > 2% > 3%, after which it was as follow: 1% > 3% > 2%. The unanticipated increase in BB release using 3% (w/v) alginate beads after two hours over that of 2% (w/v) alginate was examined by the swelling and bursting tests. The results were showing clear evidences by data and image the unusual behavior of 3% (w/v) alginate beads at two hours of swelling. This unexpected behavior for the 3% (w/v) alginate beads might be due to the higher osmotic pressure inside the beads. Overall, 2% (w/v) calcium alginate beads were considered to be the optimum formulation showing an excellent carrier for targeting drugs to the intestine, where the swelling of the beads were 60 % in the acidic medium, it was 5000 % in the alkaline medium.

References

1. W. Xiao-Peng, C. Tian-Ning, Y. Zhan-Xiao, Modelling and simulation of drug delivery from
a new type of biodegradable polymer microdevice, Sens. Actuat. A. 133 (2007) 363–367.
2. K. Akihiko, K. Minako, W. Atsushi, S. Masayasu, S. Yasuhisa, O. Teruo, Effect of Ca+2 alginate gel dissolution on release of dextran with different molecular weights, J. Control. Release. 58 (1999) 21–28.
3. W. Steve, S. Mel, L. Song–Shu, C. Err-Cheng, L. Shih-Jung, Development of a biodegradable alginate carrier system for antibiotics and bone cells, J. Orthop. Res. 25(1) (2007) 62-72.
4. G. Meera, T. Abraham, Polyionic hydrocolloids for the intestinal delivery of protein drugs: Alginate and chitosan - a review, J. Control. Release. 114 (2006)1–14.
5. R. Wayne, F. Siow, Protein release from alginate matrices, Adv. Drug Deliv. Rev. 31 (1998) 267–285.
6. A. Cappai, P. Petruzzo, G. Ruiu, T. Congiu, E. Dessy, W. Deseta, G. Cruz, G. Brotzu, Evaluation of new small barium alginate microcapsules, Int. J. Artif. Organs. 18 (1995) 95–102.
7. K. Gerd, P. Anja, R. Christoph, G. Patrik, K. Beate, H. Hans-Jürgen Z. Ulrich, Biocompatibility of mannuronic acid-rich alginates, Biomaterials. 18(10) (1997) 707-713.
8. N. Peppas, P. Buri, Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues, J. Control. Release. 2 (1985) 257-275.
9. O. Smidsrod, G. Skjak-Break, Alginate as immobilization matrix for cells, Trends Biotechnol. 8 (1990) 71-78.
10. B. Kneafsey, M. Shaughnessy, K. Condon, The use of calcium alginate dressing in deep hands
burns, Burns. 22 (1996) 40-43.
11. B. Biji, A. Jayakrishnan, Self cross-linking biopolymers as injectable in situ forming biodegradable scaffolds, Biomaterials. 26 (2005) 3941-3951.
12. G. Vandenberg, J. Noüe, Evaluation of protein release from chitosan-alginate microcapsules
produced using external or internal gelation, J. Microencapsual. 18 (4) (2001) 433–441.
13. C. Chretien, J. Chaumeil, Release of macromolecular drug from alginate-impregnated microspheres, Int. J. Pharm. 304 (2005) 18-28.
14. G. Skjak-Braek, H. Grasdalen, O. Smidsred, Inhomogeneous polysaccharide ionic gels, Carbohyd. Polym. 10 (1989) 31-54.
15. A. Anil, F. Willem, Chitosan-alginate multilayer beads for controlled release of ampicillin, Int. J. Pharm. 290 (2005) 45-54.
16. S. Bajpai, T. Rasika, Investigation of water uptake behavior and stability of calcium alginate-chitosan bi-polymeric beads: Part-1,React. Funct. Polym. 66(6) (2005) 645-658.
17. B. Arica, S. Çalis, H. Kas, M. Sargon, A. Hincal, 5- Fluorouracil encapsulated alginate beads for the treatment of breast cancer, Int. J. Pharm. 242 (2002) 267-269.
18. O. Gaserod, O. Smidsrod, G. Skjak-Braek, Microcapsules of alginate-chitosan-I A quantitative study of the interaction between alginate and chitosan, Biomaterials. 19 (1998) 1815-1825.
19. G. Mayur, C. Rajshree, M. Jolly, B. Vijay, Papain entrapment in alginate beads for stability improvement and Site-Specific Delivery: physicochemical characterization and factorial optimization using neural network modeling, AAPS, Pharm. Sci. Tech. 6 (2) (2005) Article 31.
20. K. Chong-Kook, L. Eun-Jin, The controlled release of blue dextran from alginate beads, Int. J. Pharm. 79 (1992)11–19.
21. T. Yotsuyanagi, T. Ohkubo, T. Ohhashi, K. Ikeda, Calcium induced gelation of alginic acid and pH-sensitive reswelling of dried gels, Chem. Pharma. Bull. 35(4) (1987) 1555–1563.
22. X. Shi, Y. Du, J. Li, X. Su, J. Yang, Release characteristics of brilliant blue from calciumalginate beads coated with quaternized chitosan, J. Microencapsulation. 23(4) (2006) 405–415.
23. B. Arica, S. Calis, P. Atilla, N. Durlu, N. Cakar, H. Kas, A. Hincal, In vitro and in vivo studies of ibuprofen-loaded biodegradable alginate beads, J. of Microencapsul. 22(2) (2005) 153-165.
24. N. Ali, T. Anish, In situ cross-linking of sodium alginate with calcium and aluminium ions to sustain the release of theophylline from polymeric matrices, IL Farmaco. 59 (2004) 999- 1004.
25. D. Bhopatkar, A. Anal, W. Stevens, Ionotropic alginate beads for controlled intestinal protein delivery: effect of chitosan and barium counter ions on entrapment and release, J. Microencapsul. 22(1) (2005) 91-100.
26. K. Anil, B. Deepak, T. Seiichi, T. Hiroshi, F. Willem, Chitosan-alginate multilayer beads for gastric passage and controlled intestinal release of protein, Drug dev. Ind. pharm. 29(6) (2003) 713-724.
27. A. Dainty, K. Goulding, P. Robinson, I. Sinpkins, M. Trevan, Stability of alginateimmobilized algal cells, Biotechnol. Bioeng. 28 (1986) 210-216.
28. S. Pornsak, T. Nartaya, K. Kingkarn, Swelling, erosion and release behavior of alginate-based matrix tablets, Eur. J. Pharm. Biopharm. 66 (2007) 435–450.
29. X. Shu, K. Zhu, The release behaviour of brilliant blue from calcium–alginate gel beads coated by chitosan: the preparation method effect, Eur. J. Pharm. Biopharm. 53 (2002) 193–201.
30. A. Sezer, J. Akbuga, Release characterization of chitosan treated alginate beads: II. Sustained release of low molecular weight drug from chitosan treated alginate beads, J. Microencapsul. 16(6) (1999) 687-696.
31. P. George, B. Nikolaos, Swelling studies and in vitro release of verapamil from calcium alginate and calcium alginate–chitosan beads, Eur. J. Pharm. Biopharm. 323 (2006) 34–42.
32. C. Ouwerx, N. Velings, M. Mestdagh, M. Axelos, Physico-chemical properties and rheology of alginate gel beads formed with various divalent cations, Poly. Gels Networks. 6 (1998) 393–408.

Downloads

Published

2011-01-22

How to Cite

Elnashar, M. M., Yassin, M. A., Abdel Moneim, A. E.-F., & Abdel Bary, E. M. (2011). Investigating the Unexpected Behavior for the Release Kinetics of Brilliant Blue Encapsulated into Calcium Alginate Beads. Eurasian Chemico-Technological Journal, 12(1), 69–77. https://doi.org/10.18321/ectj209

Issue

Vol. 12 No. 1 (2010)

Section

Articles

License

You are free to: Share — copy and redistribute the material in any medium or format. Adapt — remix, transform, and build upon the material for any purpose, even commercially.

Eurasian Chemico-Technological Journal applies a Creative Commons Attribution 4.0 International License to articles and other works we publish.

Subject to the acceptance of the Article for publication in the Eurasian Chemico-Technological Journal, the Author(s) agrees to grant Eurasian Chemico-Technological Journal permission to publish the unpublished and original Article and all associated supplemental material under the Creative Commons Attribution 4.0 International license (CC BY 4.0).

Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.