New Perspectives in Therapy of Intoxications by Organophosphoric Compounds

Authors

  • V. Sunel Al. I. Cuza" University, Faculty of Chemistry, Department of Organic Chemistry, Bd. Carol, 11, 6600 Iasi, Romania
  • M. Popa "Gh.Asachi" Technical University, Faculty of Industrial Chemistry, Department of Macromolecules, Bd. D. Mangeron, 71 A, 700050 Iasi, Romania
  • C. L. Dumitriu "Gh.Asachi" Technical University, Faculty of Industrial Chemistry, Department of Macromolecules, Bd. D. Mangeron, 71 A, 700050 Iasi, Romania
  • O. Pintilie "Al. I. Cuza" University, Faculty of Chemistry, Department of Organic Chemistry, Bd. Carol, 11, 6600 Iasi, Romania

DOI:

https://doi.org/10.18321/ectj320

Abstract

Little references actually exist on neutralization therapy which could constitute the missing ring from an
efficient treatment. As structural model capable to interact with organophosphoric substances, at the level of phosphor (P) atom, the common chemical element of the hole class of substances, was proposed those of benzimidazole. Different quantities of benzimidazole were put in contact with a fix quantity of trichlorphon in acid conditions and formation of a new compound was evidentiated by infrared spectrometry. Similar experiments were made utilizing benzimidazole derivatives (2 methyl or 2 benzyl benzimidazole) and different temperatures: 35 °C and 40 °C. By increasing massic rate: benzimidazole/triclorfon as well an increased reaction temperature, have favourably influenced trichlorphon capture. The obtained results justified an continuation of researches in the direction of new compounds with a structure similar with that of benzimidazole for funding an efficient neutralization therapy for organophosphoric substances.

References

1. Bologa, C., Frasin, M., Hurjui, V., Lionte, C., PetriS, O., Sorodoc, L., Urgente toxicologice in practica medicala, Editura Cantes, 1998.

2. Sunel V., Basu C., Oniscu C., Drochioiu G. Romanian biotechnological letters, (2001), Vol.6, No 6, 469-476.

3. WHO - Environmental health criteria 182, Triclorphone, World Health Organisation Geneva, (1992), 58-108.

4. Zinkl, J.G., Ch.J. Hennys & L.R. Dewelse, Bull Environ Contam Toxicol, (1977)17(4): 379-386.

5. Hayes R.H., proprietary study report No. 1039 submitted to W.H.O. by Bayer A.G., Germany, (1988).

6. Mahendru, V.K. and Agarwal R.A., Acta pharmacol. Toxicol., (1981), 48: 377-381.

Downloads

Published

2003-12-10

How to Cite

Sunel, V., Popa, M., Dumitriu, C. L., & Pintilie, O. (2003). New Perspectives in Therapy of Intoxications by Organophosphoric Compounds. Eurasian Chemico-Technological Journal, 5(4), 319–322. https://doi.org/10.18321/ectj320

Issue

Vol. 5 No. 4 (2003)

Section

Articles

License

You are free to: Share — copy and redistribute the material in any medium or format. Adapt — remix, transform, and build upon the material for any purpose, even commercially.

Eurasian Chemico-Technological Journal applies a Creative Commons Attribution 4.0 International License to articles and other works we publish.

Subject to the acceptance of the Article for publication in the Eurasian Chemico-Technological Journal, the Author(s) agrees to grant Eurasian Chemico-Technological Journal permission to publish the unpublished and original Article and all associated supplemental material under the Creative Commons Attribution 4.0 International license (CC BY 4.0).

Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.