Production Technology of Phytopreparations Based on Essential Oils
DOI:
https://doi.org/10.18321/ectj893Abstract
The article provides an overview of phytopreparations technology based on essential oils, in particular: criteria for the selection of components, qualitative and quantitative compositions analyzes, parameters of the technological cycle of production of drugs, problems of standardization and quality control of stages of the production of original drugs. A number of standard samples based on terpenoids for phased quality control of the production of medicinal products are described, which are included in the European, Kazakhstan and Japanese pharmacopeias. The main countries producing essential oils and their components, as well as manufacturers of phytopreparations based on them are indicated. The modern technologies for the production of essential oils from plant materials are reviewed, namely: microwave and ultrasonic extractions, supercritical carbon dioxide extraction and micro-steam distillation with solid phase microextraction. The dosage forms of preparations based on essential oils (tablets, ointments, gels, oil solutions, suppositories, sprays, aerosols, nanocapsules), their relationship with bioavailability and therapeutic effect are discussed. Promising dosage forms that ensure dosage accuracy for the targeted action of drugs based on essential oils have been identified.
References
(1). Essential Oils Market Size, Share & Trends Analysis Report By Application (Cleaning & Home, Medical, Food & Beverages, Spa & Relaxation), By Product, By Sales Channel, And Segment Forecasts, 2019-2025. Report ID: 978-1-68038-549-6, 2019, 187 p.
(2). D.H. De Oliveira, P.B. Abib, R.X. Giacomini, E.J. Lenardão, G. Schiedeck, E.A. Wilhelm, C. Luchese, L. Savegnago, R.G. Jacob, J. Essent. Oil Res. 31 (2019) 160‒169. Crossref
(3). C.M. Cook, T. Lanaras, Encyclopedia of Food and Health 7 (2016) 552–557. Crossref
(4). D.I. Pisarev, О.О. Novikov, Scientific reports of Belgorod State University. Series: Medicine. Pharmacy [Nauchnye vedomosti Belgorodskogo gosudarstvennogo universiteta. Serija: Medicina. Farmacija] 10 (2012) 2–5 (in Russian).
(5). E.V. Cherkashina, Scientific notes of Petrozavodsk State University [Uchenye zapiski petrozavodskogo gosudarstvennogo universiteta] 2 (2014) 77–79 (in Russian).
(6). L. Lesage-Meessen, M. Bou, J.-C. Sigoillot, C.B. Faulds, A. Lomascolo, Appl. Microbiol. Biot. 99 (2015) 3375–3385. Crossref
(7). L.A. Khlypenko, O.M. Shevchuk, N.N. Bakova, S.A. Feskov, Collection of scientific papers of Nikitsky State Botanical Garden [Sbornik nauchnikh trudov gosudarstvennogo Nikitskogo Botanicheskogo Sada] 141 (2015) 118–126 (in Russian).
(8). GOST ISO 1342-2017. Essential oil of rosemary (Rosmarinus officinalis L.). Specifications. Minsk, Euro-Asian council for standardization, metrology and certification Publ., 2017, 12 p. (in Russian)
(9). GOST ISO 9776-2017. Essential oil of Mentha arvensis, partially dementholized (Mentha arvensis L. var. piperascens Malinv. and var. glabrata Holmes). Specifications. Minsk, Euro- Asian council for standardization, metrology and certification Publ., 2017, 12 p. (in Russian).
(10). GOST ISO 3515-2017. Essential oil of lavender Lavandula angustifolia Mill. Specifications. Moscow, Standartinform Publ., 2017, 12 p. (in Russian).
(11). GOST ISO 3516-2018. Essential oil of coriander fruits (Coriandum sativum L.). Specifications. Moscow, Standartinform Publ., 2018, 12 p. (in Russian).
(12). GOST ISO 9842-2017. Essential oil of Rosa х damascene Miller. Specifications. Moscow, Standartinform Publ., 2017, 8 p. (in Russian).
(13). GOST ISO 3044-2017. Essential oil of Eucalyptus citriodora Hook. Specifications. Moscow, Standartinform Publ., 2017, 8 p. (in Russian).
(14). J. Carberry, Extraction of essential oils. Patent CA, no. 3046630, 2017.
(15). Han Shaowei, Liu Fengshan, Fan Zhiwei, Kong Weijun, Li Ying, Zhang Yan, Yang Zhen. Continuous steam distillation extraction element of woody essential oil and device system thereof. Patent CN, no. 208791601, 2018.
(16). O.G. Pankiv, V.V. Polyanskaya, V.N. Parshikova, R.A. Stepen. Sposob polucheniya efirnogo masla [Method of obtaining extraction ether oil]. Patent RF, no. 2396309, 2009 (in Russian).
(17). A.М. Aliev, G.V. Stepanov, Sposob polucheniya efirnogo masla iz shalfeya lekarstvennogo [Method of obtaining essential oil from common sage]. Patent RF, no. 2360953, 2007 (in Rissian).
(18). P.M. Kumbakisaka, S.A. Renaud, Process and installation for extraction of biological active compounds from plants and continuous reactor for ultrasound and microwave assisted extraction of biological active compounds from plants. Patent WO, no. 2016/118034, 2016.
(19). A.S. Gavrilov, Pharmaceutical technology. Manufacturing of drugs. [Farmatsevticheskaya tekhnologiya. Izgotovlenie lekarstvennikh preparatov]. Moscow: GEOTAR-Media., 2016, 760 p. (in Russian).
(20). S.А. Minina, E.Е. Kaukhova. Chemistry and technology of phytopreparations [Khimiya i tekhnologiya fitopreparatov]. Moscow: GEOTAR-Media., 2009, 560 p. (in Russian).
(21). V.А. Jurkiv, V.I. Pokrovskij, S.V. Berezkina, Т.D. Cherkasova, G.N. Tenkova, V.T. Lisovenko. Antiparazitarnaya, antibakterialnaya, protivovospalitelnaya maz’ prolongirovannogo deistviya [Antiparasitic, antibacterial, anti-inflammatory ointment showing prolonged effect]. Patent RF, no.2149007, 1999 (in Russian).
(22). Kh.S. Rustamov, A.L. Shabanov, I.N. Tjurenkov, B.B. Sysuev, А.А. Ozerov. Maz’ doktora Rustanova [Doctor Rustamov's ointment], Patent RF, no. 2527335, 2013 (in Rissian).
(23). T.G. Yarnykh, О.А. Garkantseva, V.N. Chushenko, Pharm Chem. J. 45 (2012) 750‒753. Crossref
(24). S.A. Kalinichenko, V.F. Korsun, A.S. Kalinichenko, A.S. Kalinichenko, E.V. Korsun. Sredstvo “Rectofit 1” [Rectofit 1 preparation]. Patent RF, no. 2470659, 2011 (in Russian).
(25). S.A. Kalinichenko, V.F. Korsun, A.S. Kalinichenko, A.S. Kalinichenko, E.V. Korsun, Sredstvo “Rectofit 2” [Rectofit 2 preparation]. Patent RF, no. 2470660, 2011 (in Russian).
(26). L.V. Gavashelishvili, Development of the composition and technology of lingual tablets, containing dense extract of chlorophyllipt and liquid extract of Thymus: Abstract of the dissertation of the candidate of pharmaceutical sciences, 14 April 2001, Pyatigorsk, 123 p. (in Russian).
(27). V.V. Vishnyakov, E.V. Sinkov, Russian Medical Journal [Russkiy meditsinskii zhurnal] 11 (2013) 587‒592 (in Russian).
(28). P.G. Mizina, А.S. Gulenkov, Problems of biological, medical and pharmaceutical chemistry [Voprosy biologicheskoi, meditsinskoi i farmatsevticheskoi khimii] 2 (2018) 3‒12. (in Russian). Crossref
(29). Yu.V. Filippov, N.G. Gazizova, N.N. Avdonina, Sostav i sposob polucheniya lekarstvennogo sredstva [Composition and method of producing medicine]. Patent RF, no. 2675627, 2017 (in Russian).
(30). A.A. Krolevets, Yu.A. Tyrsin, E.E. Bykovskaya, Bulletin of the Russian Academy of Natural Sciences [Vestnik Rossiiskoi Akademii Estestvennykh nauk] 1 (2013) 77–84 (in Russian).
(31). M. Sherry, C. Charcosset, H. Fessi, H. Greige- Gerges, J. Liposome Res. 23 (2013) 268–275. Crossref
(32). Yang Ziming, Li Puwang, Li Sidong, Chen Wei, Li Yongzhen, Lu Mingzhe, Zhou Wei, Wang Chao, Wang Hui. Nano-microcapsule with blumeabalsamifera essential oil as well as preparation method and application of nano-microcapsule. Patent CN, no. 107137714A, 2017.
(33). М.М. Gubin, G.V. Azmetova, Remedium 3 (2007) 61–63 (in Russian).
(34). М.М. Gubin, G.V. Azmetova, Remedium 4 (2007) 54–55 (in Russian).
(35). В.А. Safonov, Е.Yu. Golik, N.А. Komisarenko, А.N. Komisarenko, D.V. Nikolova, D.I. Isaev, D.M. Kozhushko, Topical Preparation “Ingaliptactiveplus”. Patent WO, no. 2018084824A1, 2017.
(36). L.А. Latserus, N.М. Pinigina, F.I. Maganova, Poliaktivnaya terpenoidnaya substantsiya abisil-2, farmatsevticheskaya kompozitsiya na ee osnove I sposobi ee primeneniya [Polyactive terpenoid substance abisil-2, pharmaceutical composition on its basis and ways of its application]. Patent RF, no. 2338547, 2007 (in Russian).
(37). O.G. Bhusnure, S. Suryawanshi, S.M. Vijayendra Swamy, S.B. Gholve, P. Girm, M.J. Birajdar, Journal of Drug Delivery and Therapeutics 9 (3-s) (2019) 1058–1063. Crossref
(38). N.А. Kovalenko, Т.I. Akhramovich, G.N. Supichenko, Т.V. Sachivko, V.N. Bosak, Chemistry of raw plant materials [Himiya rastitelnogo syriya] 1 (2019) 191‒199 (in Russian). Crossref
(39). Т.S. Beztsennaya, L.I. Shulga, А.F. Piminov, On the issue of standardization of integrated phytopreparation «DENTA-FIT» Innovations in medicine and pharmacy [K voprosu standartizatii komplekstnogo fitopreparata «DENTA-FIT». Innovatsii v meditsine i farmatsii] 2015, 787– 791 (in Russian).
(40). State Pharmacopoeia of the Republic of Kazakhstan. Almaty: “Zhibek zholy” Vol. 3, 2014, 872 p. (in Russian).
(41). European pharmacopoeia 8.0. Council of Europe, Strasbourg, Vol. 2, 2014, 3655 p.
(42). G.A. Atazhanova Pharmaceutical Bulletin [Farmatsevticheskii Byulletin] 1-4 (2017) 54–67 (in Russian).
(43). The Japanese Pharmacopoeia. The Stationery Office; Seventeenth edition, 2016, 2630 р.
(44). Е. Pelyakh, V. Melnik, V. Chobanu, I. Unguryanu, Studia Universitatis Moldaviae, 1 (2015) 121–124 (in Russian).
(45). S.K. Fagodia, H.P. Singh, D.R. Batish, R.K. Kohli, Ind. Crop. Prod. 108 (2017) 708–715. Crossref
(46). W. Ding, T. Yang, F. Liu, S. Tian, Pharmacogn. Mag. 10 (2014) S1: 1–5. Crossref
(47). State Pharmacopoeia of the Republic of Kazakhstan. Almaty: “Zhibek zholy” Vol. 2, 2009, 804 p. (in Russian).
(48). L.E. Ferreira, B.I. Benincasa, A.L. Fachin, S.C. França, S.S.H.T. Contini, A.C.S. Chagas, R.O. Beleboni, Vet. Parasitol. 228 (2016) 70–76. DOI: 10.1016/j.vetpar.2016.08.011
(49). A. Abderrahim, K. Belhamel, J.-C. Chalchat, G. Figuérédo, Rec. Nat. Prod. 1 (2010) 87–90.
(50). R. Chizzola, J. Essent. Oil Bear. Pl. 21 (2018) 535– 539. Crossref
(51). K. Pramod, M.R.A. Alex, M. Singh, S. Dang, S.H. Ansari, J. Ali, J. Drug Target. 24 (2016) 24–33. Crossref
(52). V.А. Merkulov, Е.I. Sakanyan, V.I. Klimov, T.B. Shemeryankina, V.А. Yashkin, А.V. Barmin, Pharm. Chem. J. 49 (2016) 54–56. Crossref
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