Development of the Composition and Technology of a New Dental Gel with Anti-Inflammatory and Antimicrobial Action

  • S. M. Adekenov JSC «International Research and Production Holding «Phytochemistry», 100009, М. Gazaliev str. 4, Karaganda, Republic of Kazakhstan
  • A. N. Zhabayeva JSC «International Research and Production Holding «Phytochemistry», 100009, М. Gazaliev str. 4, Karaganda, Republic of Kazakhstan
  • Kh. I. Itzhanova JSC «International Research and Production Holding «Phytochemistry», 100009, М. Gazaliev str. 4, Karaganda, Republic of Kazakhstan
  • A. S. Amirzhanova JSC «International Research and Production Holding «Phytochemistry», 100009, М. Gazaliev str. 4, Karaganda, Republic of Kazakhstan
  • Zh. R. Shaimerdenova JSC «International Research and Production Holding «Phytochemistry», 100009, М. Gazaliev str. 4, Karaganda, Republic of Kazakhstan

Abstract

 The development of a dental gel that meets modern requirements for the effectiveness and safety of a medicinal product is a serious scientific study related to the selection of active and auxiliary substances, providing the necessary biopharmaceutical and rheological properties of the gel composition, standardizing the quality of the dosage form. The article presents the results of a study on the development of the composition and technology of the soft dosage form of the new dental gel «Matripin- Dent» using pharmacologically active ingredients of the sum of flavonoids from Populus balsamifera L. buds (pinostrobin, pinocembrin, chrysin, techtochrysin) and the sum of terpenoids from Matricaria chamomilla L. (bisabolol oxides A and B, chamazulene). Three bases are selected: fat, gel, and multicomponent. According to the results of pharmacological studies, the optimal composition is a gel base containing polyethylene oxide 1500 and 400. The rheological index of the gel base confirms its thixotropic properties, good spreadability, the ability of the obtained gel to extrude from the tube, and stability. The indicators of control and critical points of the technological process are determined and a technological scheme for the production of dental gel is developed.

References

(1). J.I. Pattanshetti, I. Tiwari, G. Singh, F. Tazyeen, A.S. Parihar, N. Khare, Journal of International Oral Health 8 (2016) 296‒301.

(2). N.R. Shagalieva, V.A. Kurkin, E.V. Avdeeva, I.M. Baikirov, A.E. Scherbovskikh, Fundamental studies [Fundamental Research] 10 (2013) 1490–1494 (in Russ.).

(3). V.L. Bagirova, N.B. Demina, N.A. Kulichenko, Ointments. Modern view of the dosage form, Popular science journal “Farmatsiya” [Pharmacy] 2 (2002) 24‒26 (in Russ.).

(4). B. Rescala, W. Rosalem, R.P. Teles, R.G. Fischer, A.D. Haffajee, S.S. Socransky, A. Gustafsson, C.M. Figueredo, J. Periodontol. 81 (2010) 1308–1316. Crossref

(5). K. Bansal, M.K. Rawat, A. Jain, A. Rajput, T.P. Chaturvedi, S. Singh, AAPS PharmSciTech 10 (2009) 716‒723. Crossref

(6). S.K. Yellanki, J. Singh, F. Manvi, International Journal of Pharma and Bio Sciences 1 (2010) 1‒9.

(7). R. Patel, H. Patel, A. Baria, Int. J. Drug Deliv. Technol. 4 (2009) 42‒45. Crossref

(8). N. Sapna, K.L. Vandana, J. Investig. Clin. Dent. 2 (2011) 162‒170. Crossref

(9). V. Yakovenko, D. Orlenko, L. Vyshnevska, ScienceRise: Pharmaceutical Science 5 (2019) 35‒41. Crossref

(10). M.N.A. Rahman, O.A.J.A. Qader, S. Sukmasari, A.F. Ismail, A.A. Doolaanea, Journal of Pharmaceutical Sciences and Research 9 (2017) 2633–2640.

(11). C.M. Ofner, C.M. Klech-Gelotte, J. Swarbrick, J.C. Boylan (Eds.) (2002). Gels and jellies. Vol. 2. Encyclopedia of Pharmaceutical Technology. New York; Basel: Marcel Dekker, 1327–1344.

(12). S.M. Adekenov, A.N. Zhabayeva, Kh.I. Itzhanova, N.G. Titova, Protivoparadontoznoe sredstvo [Anti-periodontal drug]. Patent RK, no. 32653, 2018 (In Russ).

(13). A.N. Zhabayeva, N.G. Titova, Kh.I. Itzhanova, S.M. Adekenov, K.D. Altynbekov, 12th International Symposium on the Chemistry of Natural Compounds, Tashkent, 2017, p. 304.

(14). Z.D. Khadzhieva, Zilfikarov I.N., E.A. Teunova, Nauchnye vedomosti Belgorodskogo gosudarstvennogo universiteta. Seriya: Meditsina. Farmatsiya [Scientific statements of Belgorod State University. Series: Medicine. Pharmacy] 22 (2010) 58‒65 (In Russ.).

Published
2020-06-30
How to Cite
[1]
S. Adekenov, A. Zhabayeva, K. Itzhanova, A. Amirzhanova, and Z. Shaimerdenova, “Development of the Composition and Technology of a New Dental Gel with Anti-Inflammatory and Antimicrobial Action”, Eurasian Chem.-Technol. J., vol. 22, no. 2, p. 117‒122, Jun. 2020.
Section
Articles