Nanostructured Carbon Materials for Biomedical Use

Authors

  • Z. A. Mansurov The Institute of Combustion Problems, 050012, Almaty, 172 Bogenbay Batyr st., Kazakhstan
  • J. M. Jandosov The Institute of Combustion Problems, 050012, Almaty, 172 Bogenbay Batyr st., Kazakhstan
  • A. R. Kerimkulova al-Farabi Kazakh National University, 050040, Almaty, al-Farabi av. 71, Kazakhstan
  • S. Azat The Institute of Combustion Problems, 050012, Almaty, 172 Bogenbay Batyr st., Kazakhstan
  • A. A. Zhubanova al-Farabi Kazakh National University, 050040, Almaty, al-Farabi av. 71, Kazakhstan
  • I. E. Digel Aachen University of Applied Sciences, 1 Heinrich-Mussmann St., 52428, Julich, Germany
  • I. S. Savistkaya al-Farabi Kazakh National University, 050040, Almaty, al-Farabi av. 71, Kazakhstan
  • N. S. Akimbekov al-Farabi Kazakh National University, 050040, Almaty, al-Farabi av. 71, Kazakhstan
  • A. S. Kistaubaeva Al-Farabi Kazakh National University
  • A. S. Kistaubaeva al-Farabi Kazakh National University, 050040, Almaty, al-Farabi av. 71, Kazakhstan

DOI:

https://doi.org/10.18321/ectj224

Abstract

One of the priority trends of carbon nanotechnology is creation of nanocomposite systems. Such carbon nanostructured composites were produced using - raw materials based on the products of agricultural waste, such as grape stones, apricot stones, rice husk. These products have a - wide spectrum of application and can be obtained in large quantities. The Institute of Combustion Problems has carried out the work on synthesis of the nanostructured carbon sorbents for multiple applications including the field of biomedicine. The article presents the data on the synthesis and physico-chemical properties of carbonaceous sorbents using physicochemical methods of investigation: separation and purification of biomolecules; isolation of phytohormone - fusicoccin; adsorbent INGO-1 in the form of an adsorption column for blood detoxification, oral (entero) sorbent - INGO-2; the study of efferent and probiotic properties and sorption activity in regard to the lipopolysaccharide (LPS), new biocomposites - based on carbonized rice husk (CRH) and cellular microorganisms; the use of CRH in wound treatment. A new material for blood detoxication (INGO-1) has been obtained. Adsorption of p-cresyl sulfate and indoxyl sulfate has shown that active carbon adsorbent can remove clinically significant level of p-cresyl sulfate and indoxyl sulfate from human plasma. Enterosorbent INGO-2 possesses high adsorption activity in relation to Gram-negative bacteria and their endotoxins. INGO-2 slows down the growth of conditionally pathogenic microorganisms, without having a negative effect on bifido and lactobacteria. The use of enterosorbent INGO-2 for sorption therapy may provide a solution to a complex problem - detoxication of the digestive tract and normalization of the intestinal micro ecology. The immobilized probiotic called "Riso-lact" was registered at the Ministry of Health of the Republic of Kazakhstan as a biologically active food additive. The developed technology is patented and provides production of the medicine in the form of freeze-dried biomass immobilized in vials.

References

1. Volkov M.Yu. Effective forms of probiotics immobilized on natural sorbents. Food ingredients. Raw materials and additives – 2007. -№ 1.– P. 48-51.

2. Reshetnikova V.I. The development of medicinal forms of preparations with immunobiological and sorption activity. J. Pharmacia. – 2002. - №5. – P. 40-44.

3. Lubarsky M.S., Letyagin A.Yu., Gabitov V.Kh. Sorption carbon-mineral preparations used in purulent-septic surgery. - Novosibirsk:, 1994. - 132 p.

4. Bone R.C. Gram-negative sepsis: a dilemma of modern medicine. Clin. Microbiol. Rev. 6, P. 57-68. 1993.

5. A.R. Kerimkulova, B.B. Mansurova, M.K. Gilmanov, Z.A. Mansurov. Nanoporous carbon sorbent for molecular sieve chromatography of protein-lipid complex. J. of Physical Chemistry, 2012, Vol. 86, № 6, P. 1-5

6. A.R. Kerimkulova, S. Azat, Z.A. Mansurov, M.K. Gilmanov, C.A. Ibragimova, S.M. Adekenov, B.B. Rakhimova., Mesoporous nano carbon sorbents for separating different biomolecules. Advanced Materials Research, Vols. 535-537 (2012) P. 284-288.

7. Ваlliо А., Chain Е.В., DeLeo P., ErlangerB.F., Mauri M., Tonolo A. Fusicoccin: a new wilting Toxin produced by Fusicoccum amygdali Del. Nature. - 1964. - Vol. 203.- № 4942. - P. 297.

8. Ingrid J. de Vries-van Leeuwenemail, Chantal Kortekaas-Thijssenemail, Jean A. Nzigou Mandouckouemail, Sjors Kasemail, Antonio Evidenteemail, Albertus H. de Boeremail. Fusicoccin-A selectively induces apoptosis in tumor cells after interferon-α priming. Cancer Letters, Volume 293, Issue 2 , P. 207-212, 2010.

9. Azat S., Pavlenko V.V, Kerimkulova A.R., Mansurov Z.A. Synthesis and structure determination of carbonized nano mesoporous materials based on vegetable raw materials. Advanced Materials Research Vols. 535-537 (2012).

10. B.N. Meyer, N.R. Ferrigni, J.E. Putnam, L.B. Jacobsen, D.E. Nichols and J.L. McLaughlin. Brine Shrimp: A Convenient General Bioassay for Active Plant Constituents. Planta Medica, 1982, V. 45, P. 31-34.

11. L. McLaughlin. Crown Gall Tumors on Potato Discs and Brine Shrimp Lethality: Two Simple Bioassays for Higher Plant Screening and Fractionation. Methods in Plant Boichemistry, 1991, V. 6, P. 1-32.

12. Ullrich H., Jakob W., Frohlich D., Rothe G., Prasser C., Drobnik W., Taeger K., MeierHellmann A., Reinhart K., Zimmermann M. and Schmitz G. A new endotoxin adsorber: first clinical application. Ther. Apher. 5, P. 326-334. 2001.

13. S.R. Sandeman, C.A. Howell, S.V. Mikhalovsky, G.J. Phillips, A.W. Lloyd, J.G. Davies, S.R. Tennison, A.P. Rawlinson, O.P. Kozynchenko, Inflammatory cytokine removal by inactivated carbon device in a flowing system // Biomaterials. – 2003. – №29 (11). – P. 1638-1644.

14. Byung - Joo Kim, Young - Seak Lee, Soo - Jin Park, Journal of Colloid and Interface Science, 306 (2007) 454.

15. The method for obtaining carbon enterosorbent INGO-2 - an application for inventions rights has been submitted - № 2011/0269.1 datel 15.03.2011.

16. Mansurov Z.A., Savickaya I.S., Kistaubaeva A.S., Biysenbaev M.A., Tuleubaeva Sh.A. Method for production of INGO-2 Carbon Enterosorbent. International publication number WO2012/138207 A1 Pub.date 11.10.2012

17. Avdeev V.G. Probiotics and prebiotics in the treatment of diseases of gastrointestinal tract. Clinical pharmacology and therapy. - 2006. – V. 15. - №1. - p. 36-40.

18. Kistaybaeva A.S., Savitzkaya I.S., Muratova F.T. Study of antagonistic properties of new strains of intestinal lactobacillus. Vestnik KazNU. Biological series. – 2007. - № 5 (35). – p. 100-103.

19. Bhinu V.S. Insight into biofilm-associated microbial life. – J.Mol.Microbiol. –2005. Vol. 3. – P.197-214.

20. Bondarenko V.M., Matzulevich T.V. Dysbacteriosis of intestin as a clinico-laboratory syndrome: current state of a problem. - М., GeotarMedia. - 2007. –305 p.

21. Savitzkaya I.S. Study of functional activity of probiotic bacteria with genetically-labeled strains // Vestnik KazNU. Biological series. - 2006. - №3. - p.78-83.

22. Certificate of authorship № 21917 datel 21.10.2008 С12N 1/20 (2006.01). – Immobilized biopreparation – probiotic «Riso-Lact». Authors of inventions: Savitzkaya I.S., Zhubanova A.A., Kistaybaeva A.S., Shupshibaev K.K.

23. Shaposhnikov Yu.G., Shalnev A.N., Bulgakov V.G. Use of carbon tissue sorbents in combination with antioxidants in wounds’ treatment. // Intern. Surgery Congress "Wounds. Burns. Dressings".- Tel-Aviv, 1998. - P. 53-55.

Downloads

Published

2013-07-25

How to Cite

Mansurov, Z. A., Jandosov, J. M., Kerimkulova, A. R., Azat, S., Zhubanova, A. A., Digel, I. E., … Kistaubaeva, A. S. (2013). Nanostructured Carbon Materials for Biomedical Use. Eurasian Chemico-Technological Journal, 15(3), 209–217. https://doi.org/10.18321/ectj224

Issue

Vol. 15 No. 3 (2013)

Section

Articles

License

You are free to: Share — copy and redistribute the material in any medium or format. Adapt — remix, transform, and build upon the material for any purpose, even commercially.

Eurasian Chemico-Technological Journal applies a Creative Commons Attribution 4.0 International License to articles and other works we publish.

Subject to the acceptance of the Article for publication in the Eurasian Chemico-Technological Journal, the Author(s) agrees to grant Eurasian Chemico-Technological Journal permission to publish the unpublished and original Article and all associated supplemental material under the Creative Commons Attribution 4.0 International license (CC BY 4.0).

Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.