Study of Immobilization by Esteric Bond of 2-(m-Nitrophenyl)-4-(ОІ- Carboxymethyl)-О”2-Oxazolinone-5 on Gellan

Authors

  • Popa Marcel Technical University “Gh.Asachi” of Iasi, Department of Macromolecules, Bd. D. Mangeron 71A, 6600 Iasi, Romania
  • Sunel Valeriu University “Al.I.Cuza” of Iasi, Departament of Organic Chemistry, Bd. Copou 11, 6600, Iasi, Romania
  • Balaita Rusu Lacramioara Technical University “Gh.Asachi” of Iasi, Department of Macromolecules, Bd. D. Mangeron 71A, 6600 Iasi, Romania
  • Basu Cristina Research&Development Department, S.C. Antibiotice S.A., 1 Valea Lupului Street, 6600 Iasi, Romania

DOI:

https://doi.org/10.18321/ectj291

Abstract

The paper studies the coupling reaction, through ester-type covalent bonds, of an oxazolone derived from the N-(m-nitrobenzoyl)-L-asparagic acid, on gellan (a polysaccharide of microbian synthesis), in conditions of activation with dicyclohexyl carbodiimide. Based on a centered, rotatory, composed, second order experimental program, the regression equation describing the dependence of the amount of active principle, chemically bounded to the support, on the reaction’s  parameters (support/active principle ratio, active principle/activator ratio, duration) is obtained. One may observe that the efficiency of the coupling reaction is maximum when employing the parameters’ highest values, over the variation domain established. The coupling product has been characterized through elemental analysis and IR spectroscopy. For the establishment  of the capacity of the active principle’s controlled release by the polymer-active principle system thus obtained, drug’s release kinetics from the polysaccharidic support is studied in conditions of basic hydrolysis. The oxazolone release from the coupling products, by basic hydrolysis proceeds conformely to a zero order kinetics, proving their retard activity.

References

(1). Sunel, V., Popa, M., Popa, A. and Soldea, C., Cellulose Chem. Technol., 34:269, (2000).

(2). Sunel, V., Basu, C., Oniscu, C. and Soldea, C., Roum. Biotechnol. Lett., 5:393, (2000).

(3). Sunel, V., Ciugureanu, C. and Ungureanu, M., Rev. Med. Chir. Soc. Med. Nat., Iasi, 98:273, (1993).

(4). Sunel, V. and Soldea, C., Comp. Rend. Acad. Bulg. Sci., 46:61, (1993).

(5). Sunel, V. and Soldea, C., Indian J. Chem., 34B:227, (1995).

(6). Soldea, C. and Sunel, V., Comp. Rend. Acad. Bulg. Sci., 48:67, (1995).

(7). Sunel, V., Ciugureanu, C. and Ungureanu, M., Rev. Med. Chir. Soc. Med. Nat., Iasi, 100:163, (1996).

(8). Sunel, V. and Basu, C., An. St. Univ. Al. I. Cuza” Iasi, 7:111, (1999).

(9). Sunel, V., Basu, C., Drochinoiu, G. and Filimon, M., Rev. Med. Chir. Soc. Med. Nat., Iasi, 105:288, (2001).

(10). Sunel, V., Basu, C., Sirbu, D., Popa, M., Diaconu, E. and Soldea, C., Acta. Pharm., 51:35, (2001).

(11). Popa, M., Rusu, L., Sunel, V. and Basu, C., Cellulose Chem. and Technol., 36, 5-6:510, (2002).

(12). S. Dumitriu, P. Vidal, E. Chornet in Dumitriu, S., (ed.), Polysaccarides in Medical Applications, Marcel Dekker, Inc., New York, 1996, p.125.

(13). S. Dumitriu, M. Dumitriu, in Dumitriu, S., (ed.), Polysaccarides in Medical Applications, Marcel Dekker, Inc., New York, 1996, p. 705.

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Published

2003-04-15

How to Cite

Marcel, P., Valeriu, S., Lacramioara, B. R., & Cristina, B. (2003). Study of Immobilization by Esteric Bond of 2-(m-Nitrophenyl)-4-(ОІ- Carboxymethyl)-О”2-Oxazolinone-5 on Gellan. Eurasian Chemico-Technological Journal, 5(2), 121–126. https://doi.org/10.18321/ectj291

Issue

Vol. 5 No. 2 (2003)

Section

Articles

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