Xanthan and Poly(vinyl alcohol) - Based Composite Films, as Supports for Chloramphenicol Immobilization

Alupei Iulian Corneliu; Popa Marcel; Hamcerencu Mihaela; Savin Alexander; Abadie Marc Jean

doi:10.18321/ectj566

Authors

Alupei Iulian Corneliu “Gr. T.Popa” University of Medicine and Pharmacy, Faculty of Medical Bioengineering, Universitatii str, nr. 16, 6600 Iasi, Romania
Popa Marcel Gh. Asachi” Technical University, Faculty of Chemical Engineering, Bd. D. Mangeron, nr. 71, 6600 Iasi, Romania
Hamcerencu Mihaela Gh. Asachi” Technical University, Faculty of Chemical Engineering, Bd. D. Mangeron, nr. 71, 6600 Iasi, Romania
Savin Alexander Gh. Asachi” Technical University, Faculty of Chemical Engineering, Bd. D. Mangeron, nr. 71, 6600 Iasi, Romania
Abadie Marc Jean LEMP/MAO, Montpellier II University, Place Eugène Bataillon, 34095 Montpellier Cedex 05, France

DOI:

https://doi.org/10.18321/ectj566

Abstract

The paper discusses a method for the realization of some polymer - drug systems in which the macromolecular support is represented by a three-dimensional network based on xanthan and poly(vinyl alcohol). Knowing that the drug (chloramphenicol) was to be inserted through a diffusion process, the support – selected according to an experimental program – had the highest degree of swelling. Several variants of chloramphenicol inclusion into the synthesized support are analyzed by studying the process kinetics. The study of chloramphenicol release from the inclusion products, in the form of films, indicated the installation of a “zero order” kinetics. The tests devoted to the system’s antimicrobial activity evidenced their biological action.

References

(1). B.T. Stokke, B.E. Christensen and O. Smidsrod, in S.Dumitriu (Ed.), Polysaccharides. Structural Diversity and Functional Versatility, Marcel Dekker, New York, 1998, p. 433.

(2). H. Park, and K. Park, in R.M.Ottenbrite, S.J.Huang and K.Park (Ed.), Hydrogels and Biodegradable Polymers for Bioapplications, ACS Symposium Series, Washington D.C., 1996, p. 2.

(3). Chuang, W.Y., Young, T.H., Yao, C.H. and Chiu, W.Y., Biomaterials, 20:1479 (1999).

(4). Dumitriu, S., Popa, M., Popa, M.I., and Dumitriu, M., Acta Polymerica, 38:2 (1987).

(5). Dumitriu, S., Popa, M., and Dumitriu, M., J.Bioact. Compat. Polym., 3:244 (1988).

(6). Dumitriu, S., Popa, M., and Dumitriu, M., J.Bioact. Compat. Polym., 3:403 (1988).

(7). Dumitriu, S., Popa, M., and Dumitriu, M., J.Bioact. Compat. Polym., 4:57 (1989).

(8). Dumitriu, S., Popa, M., and Dumitriu, M., J.Bioact. Compat. Polym., 4:151 (1989).

(9). Dumitriu, S., Popa, M., and Dumitriu, M., J.Bioact. Compat. Polym., 5:89 (1990).

(10). Dumitriu, S., Popa, M., and Beldie, C., Makromol.Chem., 19:313 (1988).

(11). Isomura, T., and Imanishi, A., J.Polym.Sci., 33:337 (1958).

(12). Dumitriu, S., Popa, M., and Lupu, A., Rom.pat., 91:654 (1986).

(13). Buiuc, D. Microbiologie medicala. Ed. Didactica si Pedagogica, Bucuresti, 1992, p. 249.

(14). Rahal Jr, JJ, and Simberkoff, M. S., Antimicrob Agents Chemother 16:13 (1979).