Microparticles on the Basis of Segmented Polyurethanes for Drug Respiratory Administration

Authors

  • Rinat Iskakov Institute of Chemical Sciences, 106 Walikhanov Street, 480100, Almaty, Kazakhstan
  • Erkesh O. Batyrbekov Institute of Chemical Sciences, 106 Walikhanov Street, 480100, Almaty, Kazakhstan
  • Bulat Zhubanov Institute of Chemical Sciences, 106 Walikhanov Street, 480100, Almaty, Kazakhstan
  • David J. Mooney Dept. Biologic&Materials Sciences, University of Michigan 3074 H.H. Dow Bldg., Ann Arbor, MI 48109-2136, USA

DOI:

https://doi.org/10.18321/ectj334

Abstract

Microparticles based on segmented polyurethane were synthesized by polycondensation of a series of diols having various molecular weight with tolyene-2,4-diisocyanate in water-in-oil emulsion. The resulting spherical microparticles were 6-10 µm in diameter following the Gauss distribution. The size of microcapsules at maximum distribution band increases with growing PEG length. It was observed that with higher length of PEG wall surfaces of capsules become more stable mechanically, however a capsule itself is no more brittle and rough. Some aggregation also occurs for microparticles based on PEG 4200. Since respiratory way of drug administration considers size of particles within 1-10 µm as the most applicable, the resulting PU microparticles could be an ideal candidate as domain for respirable antiTB drug administration.

References

(1). Zhubanov B. A., Batyrbekov E. O., Iskakov R. Polymeric Materials with Therapeutic Activity. Almaty, 2000, 220 pp. (in Russian).

(2). Fong J. W. in Controlled Release Systems: Fabrication Technology. V.1, Hsieh D. ed., CRCPress, Boca Raton, Florida, 1990, 81.

(3). Saraf V.P., Glasser W.G., Wilkes G.L. J. Appl. Polym. Sci., 1985, 30, 2207.

(4). Frere Y., Danicher L., Gramain P. Eur. Polym. J., 1998, 34, 193.

(5). Timothy G. R., Glasser W. G. Holzforschung, 1984, 38, 263.

(6). Bikales H. Encyclopedia Polym. Sci. & Engineering, V. 2, 3-rd edn. Wiley Interscience, NY, 1987.

(7). Respiratory System. In Bloom K. Fawcett (ed.) Text Book of Histology. Second Ed. Wiley& Sons. NY, 1996, 731.

(8). P. O’Hara, A. J. Hickey. Pharmaceutical Research, 2000, 17, 955.

Downloads

Published

2004-03-25

How to Cite

Iskakov, R., Batyrbekov, E. O., Zhubanov, B., & Mooney, D. J. (2004). Microparticles on the Basis of Segmented Polyurethanes for Drug Respiratory Administration. Eurasian Chemico-Technological Journal, 6(1), 51–55. https://doi.org/10.18321/ectj334

Issue

Vol. 6 No. 1 (2004)

Section

Articles

License

You are free to: Share — copy and redistribute the material in any medium or format. Adapt — remix, transform, and build upon the material for any purpose, even commercially.

Eurasian Chemico-Technological Journal applies a Creative Commons Attribution 4.0 International License to articles and other works we publish.

Subject to the acceptance of the Article for publication in the Eurasian Chemico-Technological Journal, the Author(s) agrees to grant Eurasian Chemico-Technological Journal permission to publish the unpublished and original Article and all associated supplemental material under the Creative Commons Attribution 4.0 International license (CC BY 4.0).

Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.

Most read articles by the same author(s)