Synthesis, Structure and Antiradical Activity of Functionally Substituted Hydrazides of Isonicotinic Acid

Authors

  • O.A. Nurkenov Karaganda Industrial University, 30 Republic Ave., Temirtau, Kazakhstan; Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, 1 Alikhanov str., Karaganda, Kazakhstan
  • S.D. Fazylov Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, 1 Alikhanov str., Karaganda, Kazakhstan
  • Z.T. Shulgau National Center for Biotechnology, 13/5, Kurgalzhynskoye road, Astana, Kazakhstan
  • B.S. Abdrasilov Karaganda Industrial University, 30 Republic Ave., Temirtau, Kazakhstan
  • A.I. Khlebnikov National Research Tomsk Polytechnic University, 30 Lenin Ave., Tomsk, Russia; Altai State University, 61 Lenin Ave., Barnaul, Russia
  • T.M. Seilkhanovv Sh. Ualikhanov Kokshetau University, 76 Abay str., Kokshetau, Kazakhstan
  • S.K. Kabieva Karaganda Industrial University, 30 Republic Ave., Temirtau, Kazakhstan
  • G.Zh. Karipova Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, 1 Alikhanov str., Karaganda, Kazakhstan

DOI:

https://doi.org/10.18321/ectj1502

Keywords:

Isoniazid, Aromatic aldehydes, Two-dimensional spectra, 1H and 13C NMR, X-ray diffraction

Abstract

The purpose of this work is the synthesis of new isonicotinic acid hydrazones, the study of their structure, reactivity and biological screening of some synthesized compounds. The reactions leading to new N-arylidene(alkylidene) hydrazones via the condensation of isonicotinic acid hydrazide with various derivatives of aromatic aldehydes were studied. The structure of the new functionally substituted isonicotinic acid hydrazones was established by FTIR, 1H and 13C NMR, two-dimensional COSY (1H-1H) NMR spectroscopy and HMQC (1H-13C). The antiradical activity of the synthesized derivatives was studied using diphenylpycrylhydrazide radical (DPPH) assay. It was shown that N-(3- ethoxy-4-hydroxybenzylidene)isonicotinohydrazide possesses antiradical activity (IC50 (DPPH) 103.0 μM). The antiradical properties of compounds of phenolic nature are in agreement with the energies of homolytic O-H bond dissociation calculated with the use of density functional theory.

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Published

15-07-2023

How to Cite

Nurkenov, O., Fazylov, S., Shulgau, Z., Abdrasilov, B., Khlebnikov, A., Seilkhanovv, T., … Karipova, G. (2023). Synthesis, Structure and Antiradical Activity of Functionally Substituted Hydrazides of Isonicotinic Acid. Eurasian Chemico-Technological Journal, 25(2), 121–128. https://doi.org/10.18321/ectj1502

Issue

Vol. 25 No. 2 (2023)

Section

Article

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