Synthesis and Anti-Inflammatory Activity of New Nicotinoyl Amides

Authors

  • O.A. Nurkenov Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, 1 Alikhanov str., Karaganda, Kazakhstan; Karaganda Industrial University, 30 Republic Ave., Temirtau, Kazakhstan
  • S.D. Fazylov Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, 1 Alikhanov str., Karaganda, Kazakhstan
  • Zh.S. Nurmaganbetov Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, 1 Alikhanov str., Karaganda, Kazakhstan
  • T.M. Seilkhanov Sh. Ualikhanov Kokshetau University, 76 Abay str., Kokshetau, Kazakhstan
  • A.Zh. Mendibayeva Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, 1 Alikhanov str., Karaganda, Kazakhstan; Karaganda Industrial University, 30 Republic Ave., Temirtau, Kazakhstan
  • S.K. Kabieva Karaganda Industrial University, 30 Republic Ave., Temirtau, Kazakhstan
  • E.M. Satbaeva Asfendiyarov Kazakh National Medical University, 94 Tole bi str., Almaty, Kazakhstan

DOI:

https://doi.org/10.18321/ectj1640

Keywords:

nicotinic acid, chloranhydride, morpholine, cytisine, 1-adamantane, antiflammatory activity, NMR spectroscopy

Abstract

The article presents the results of a study of the amination reaction of nicotinic acid chlorohydride with amines morpholine, cytisine, and 1-aminoadamantane, which are often used in the search and creation of drugs for respiratory and circulatory stimulants. The study was conducted to search for new biologically active compounds with anti-inflammatory activity. The synthesis of new aminoamides was carried out by the interaction of nicotinic acid with molecules of morpholine, cytisine, and adamantane in anhydrous ethanol. As a result of the conducted studies, new amides of nicotinic acid with high yields (90.7–93.1%) were obtained. The structures of the new compounds were determined using NMR 1H and 13C spectroscopy methods, as well as data from two-dimensional spectra of COSY (1H-1H), HMQC (1H-13C), HMBC (1H-13C) and mass spectrometry. The results of an experimental study of the anti-inflammatory activity of synthesized new amides are presented. The anti-inflammatory effect of nicotinic acid N-adamantylamide was established, other new amides were ineffective compared with ibuprofen (p2 < 0.05).

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Published

22-10-2024

How to Cite

Nurkenov, O., Fazylov, S., Nurmaganbetov, Z., Seilkhanov, T., Mendibayeva, A., Kabieva, S., & Satbaeva, E. (2024). Synthesis and Anti-Inflammatory Activity of New Nicotinoyl Amides. Eurasian Chemico-Technological Journal, 26(3), 169–174. https://doi.org/10.18321/ectj1640

Issue

Vol. 26 No. 3 (2024)

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Articles

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