Novel 7-Aryliden-3,3a,4,5,6,7-(hexahydro-5-(2-ethoxyethyl)-2-phenyl- 3-aryl-2H-pyrazolo[4,3-c]pyridine Hydrochloride: Synthesis and Structure

Authors

  • Zh.A. Koshetova A.B. Bekturov Institute of Chemical Sciences, 106, Ualikhanov str., Almaty, Kazakhstan; Kazakh National Women’s Teacher Training University, 99, Ayteke bi str., Almaty, Kazakhstan
  • V.K. Yu A.B. Bekturov Institute of Chemical Sciences, 106, Ualikhanov str., Almaty, Kazakhstan
  • T.K. Iskakova A.B. Bekturov Institute of Chemical Sciences, 106, Ualikhanov str., Almaty, Kazakhstan
  • N.A. Zhumanova A.B. Bekturov Institute of Chemical Sciences, 106, Ualikhanov str., Almaty, Kazakhstan; Kazakh National Women’s Teacher Training University, 99, Ayteke bi str., Almaty, Kazakhstan
  • K.M. Beketov A.B. Bekturov Institute of Chemical Sciences, 106, Ualikhanov str., Almaty, Kazakhstan
  • A.E. Malmakova A.B. Bekturov Institute of Chemical Sciences, 106, Ualikhanov str., Almaty, Kazakhstan
  • K.D. Praliyev A.B. Bekturov Institute of Chemical Sciences, 106, Ualikhanov str., Almaty, Kazakhstan
  • T.M. Seilkhanov Sh. Ualikhanov State University, 76, Abai str., Kokshetau, Kazakhstan
  • K.D. Berlin Oklahoma State University, Stillwater, 74078, USA

DOI:

https://doi.org/10.18321/ectj1147

Keywords:

7-arylidene-3,3a,4,5,6,7-(hexa¬hydro-5-(2-ethoxyethyl)-2-phe¬nyl-3-aryl-2H-pyrazolo[4,3-c] pyridine, heterocyclisation, X-ray crystal structure

Abstract

A Claisen-Schmidt type reaction of 1-(2-ethoxyethyl)piperidin-4-one with differ­ent aromatic aldehydes led to corresponding dienones with a yield of 65‒71%. 7-Arylidene-3,3a,4,5,6,7-(hexahydro-5-(2-ethoxyethyl)-2-phenyl-3-aryl-2H-pyrazolo[4,3-c]pyridines were synthesized by heterocyclization of 3,5-dia­rylidene-piperidin-4-ones with phenylhydrazine hydrochloride in methanol at 70 °C over 4‒6 h. The X-ray crystal structure determination of 7-(p-methoxy­benzyliden)-3,3a,4,5,6,7-(hexahydro-5-(2-ethoxyethyl)-2-phenyl-3-(p-methoxy­phenyl)-2H-pyrazolo[4,3-c]pyridine hydrochloride (the deposition number is CCDC 862410) was completed. The piperidine and pyrazoline rings are close to a chair and envelope conformations, respectively.

 

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Published

2022-03-31

How to Cite

Koshetova, Z., Yu, V., Iskakova, T., Zhumanova, N., Beketov, K., Malmakova, A., … Berlin, K. (2022). Novel 7-Aryliden-3,3a,4,5,6,7-(hexahydro-5-(2-ethoxyethyl)-2-phenyl- 3-aryl-2H-pyrazolo[4,3-c]pyridine Hydrochloride: Synthesis and Structure. Eurasian Chemico-Technological Journal, 24(1), 43–50. https://doi.org/10.18321/ectj1147

Issue

Vol. 24 No. 1 (2022)

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Articles

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