Novel 7-Aryliden-3,3a,4,5,6,7-(hexahydro-5-(2-ethoxyethyl)-2-phenyl- 3-aryl-2H-pyrazolo[4,3-c]pyridine Hydrochloride: Synthesis and Structure

  • Zh.A. Koshetova A.B. Bekturov Institute of Chemical Sciences, 106, Ualikhanov str., Almaty, Kazakhstan; Kazakh National Women’s Teacher Training University, 99, Ayteke bi str., Almaty, Kazakhstan
  • V.K. Yu A.B. Bekturov Institute of Chemical Sciences, 106, Ualikhanov str., Almaty, Kazakhstan
  • T.K. Iskakova A.B. Bekturov Institute of Chemical Sciences, 106, Ualikhanov str., Almaty, Kazakhstan
  • N.A. Zhumanova A.B. Bekturov Institute of Chemical Sciences, 106, Ualikhanov str., Almaty, Kazakhstan; Kazakh National Women’s Teacher Training University, 99, Ayteke bi str., Almaty, Kazakhstan
  • K.M. Beketov A.B. Bekturov Institute of Chemical Sciences, 106, Ualikhanov str., Almaty, Kazakhstan
  • A.E. Malmakova A.B. Bekturov Institute of Chemical Sciences, 106, Ualikhanov str., Almaty, Kazakhstan
  • K.D. Praliyev A.B. Bekturov Institute of Chemical Sciences, 106, Ualikhanov str., Almaty, Kazakhstan
  • T.M. Seilkhanov Sh. Ualikhanov State University, 76, Abai str., Kokshetau, Kazakhstan
  • K.D. Berlin Oklahoma State University, Stillwater, 74078, USA
Keywords: 7-arylidene-3,3a,4,5,6,7-(hexa¬hydro-5-(2-ethoxyethyl)-2-phe¬nyl-3-aryl-2H-pyrazolo[4,3-c] pyridine, heterocyclisation, X-ray crystal structure

Abstract

A Claisen-Schmidt type reaction of 1-(2-ethoxyethyl)piperidin-4-one with differ­ent aromatic aldehydes led to corresponding dienones with a yield of 65‒71%. 7-Arylidene-3,3a,4,5,6,7-(hexahydro-5-(2-ethoxyethyl)-2-phenyl-3-aryl-2H-pyrazolo[4,3-c]pyridines were synthesized by heterocyclization of 3,5-dia­rylidene-piperidin-4-ones with phenylhydrazine hydrochloride in methanol at 70 °C over 4‒6 h. The X-ray crystal structure determination of 7-(p-methoxy­benzyliden)-3,3a,4,5,6,7-(hexahydro-5-(2-ethoxyethyl)-2-phenyl-3-(p-methoxy­phenyl)-2H-pyrazolo[4,3-c]pyridine hydrochloride (the deposition number is CCDC 862410) was completed. The piperidine and pyrazoline rings are close to a chair and envelope conformations, respectively.

 

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Published
2022-03-31
How to Cite
[1]
Z. Koshetova, “Novel 7-Aryliden-3,3a,4,5,6,7-(hexahydro-5-(2-ethoxyethyl)-2-phenyl- 3-aryl-2H-pyrazolo[4,3-c]pyridine Hydrochloride: Synthesis and Structure”, Eurasian Chem.-Technol. J., vol. 24, no. 1, pp. 43-50, Mar. 2022.
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Articles