Biologically Active Terpenoids Ligularia Macrophylla (Ledeb.) DC. аnd Technology of New Drug Substance

Authors

  • S.M. Adekenov JSC “Research and Production Center “Phytochemistry”, 100009, Karaganda, Republic of Kazakhstan
  • V.L. Ugay NJSC “Karagandy University of the name of academician E.A. Buketov“, 100026, Karaganda, Republic of Kazakhstan
  • G.M. Kadirberlina NJSC “Karagandy University of the name of academician E.A. Buketov“, 100026, Karaganda, Republic of Kazakhstan
  • B.S. Adekenov JSC “Research and Production Center “Phytochemistry”, 100009, Karaganda, Republic of Kazakhstan
  • E.A. Krasnokutskaya National Research Tomsk Polytechnic University, 634050, Tomsk, Russian Federation

DOI:

https://doi.org/10.18321/ectj1610

Keywords:

Ligularia macrophylla (Ledeb.) DC, extraction, hydrodistillation, microwave extraction, essential oil, furanoeremophilan-14β,6α-olide, mathematical modeling, biological activity

Abstract

The article presents the results of a chemical study of Ligularia macrophylla (Ledeb.) DC. The essential oil was isolated by hydrodistillation using a Clevenger apparatus and microwave extraction using a NEOS installation. Using mass spectrometry, 52 components were identified in the essential oil isolated by hydrodistillation; 63 components were identified in the essential oil isolated by microwave extraction. The main components of the essential oil are Δ3-carene, β-bisabolene, β-myrcene. It was revealed that the substance obtained from the essential oil of Ligularia macrophylla (Ledeb.) DC. has anti-inflammatory and antimicrobial activity. For the first time, the optimal technological parameters for alcohol extraction of Ligularia macrophylla (Ledeb.) DC roots were determined using the method of mathematical modeling, providing a quantitative yield of the sesquiterpene lactone furanoeremophilan-14β,6α-olide, which has anti-inflammatory activity.

 

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Published

2024-06-27

How to Cite

Adekenov, S., Ugay, V., Kadirberlina, G., Adekenov, B., & Krasnokutskaya, E. (2024). Biologically Active Terpenoids Ligularia Macrophylla (Ledeb.) DC. аnd Technology of New Drug Substance . Eurasian Chemico-Technological Journal, 26(2), 75–84. https://doi.org/10.18321/ectj1610

Issue

Vol. 26 No. 2 (2024)

Section

Articles

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