Phytosomes – an Effective Drug-Delivery System. Development, Technology, Application.

Abstract

Herbal ingredients are widely used in practice due to their broad pharmacological effects and absence of side effects. However, despite their remarkable pharmacodynamic activity, most of the herbal ingredients have shown lower bioavailability in vivo conditions. New drug-delivery systems acquired vital importance because of higher bioavailability and overall therapeutic efficacy. A review of various studies on the production and application of phytosomal medical forms, which are in the form of hybrid molecules with high solubility in lipid and aqueous environments, is presented in this article. In an aquatic environment phytosomes group and form micelles. Phytosomes are used for increasing the bioavailability of the medical component, targeted delivery, and increasing the effect of the action of a medical drug while decreasing its therapeutic dose. Expanding the range of phytosomal medicinal forms, including sesquiterpene lactones, flavonoids, and other hydrophilic compounds is a perspective direction. In literary sources, methods for establishing quality control are practically absent and require development as well as unification.