PCL Based CIP-Loaded Double-Layer Films Deposited by Low-Electron Beam Dispersion Method and its Antibacterial Properties

Qin Xu; Beibei Li; Zhengwei Xu; Xiaohong Jiang; M.A. Yarmolenko; A.A. Rogachev; A.V. Rogachev

doi:10.18321/ectj997

Authors

Qin Xu International Chinese-Belorussian Scientific Laboratory on Vacuum-Plasma Technology, Nanjing University of Science and Technology, 200, Xiaolingwei str., Nanjing 210094, China
Beibei Li International Chinese-Belorussian Scientific Laboratory on Vacuum-Plasma Technology, Nanjing University of Science and Technology, 200, Xiaolingwei str., Nanjing 210094, China
Zhengwei Xu International Chinese-Belorussian Scientific Laboratory on Vacuum-Plasma Technology, Nanjing University of Science and Technology, 200, Xiaolingwei str., Nanjing 210094, China
Xiaohong Jiang International Chinese-Belorussian Scientific Laboratory on Vacuum-Plasma Technology, Nanjing University of Science and Technology, 200, Xiaolingwei str., Nanjing 210094, China
M.A. Yarmolenko Francisk Skorina Gomel State University, 104, Sovetskaya str., Gomel 246019, Belarus
A.A. Rogachev Francisk Skorina Gomel State University, 104, Sovetskaya str., Gomel 246019, Belarus
A.V. Rogachev Francisk Skorina Gomel State University, 104, Sovetskaya str., Gomel 246019, Belarus

DOI:

https://doi.org/10.18321/ectj997

Keywords:

Low-electron beam dispersion, Polycaprolactone, Polyurethane, Ciprofloxacin, Antibacterial activity, Drug release

Abstract

In this paper, low-electron beam dispersion (EBD) method is used to prepare a kind of double-layer films on different substrates. The bottom layer is a mechanically stirred mixture of the degradable polycaprolactone (PCL) and ciprofloxacin (CIP), and the top layer is polyurethane (PU) film. The molecular structure, chemical composition and morphology of the double-layer films were investigated by FTIR, XPS and SEM. The results showed that the surfaces of the double-layer films are uniform and the thicknesses can reach micron level. In addition, the two layers are well bonded. Then the films were sliced and immersed in PBS solution, and the time-dependent variable was used to analyze the kinetic slow-release behavior of CIP in the double-layer films by agar diffusion antibacterial experiments. It can be seen that sustained release time of CIP in the double-layer films can be up to 7 days, which is due to fact that the upper PU film working as a sealing layer helps to realize the drug slow-release. Based on the above research, the comprehensive performance of the films with the composition of PCL:CIP/PU=1:1/1 is the best.

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