Obtaining of Biologically Soluble Membranes Based on Polymeric Nanofibres and Hydroxyapatite of Calcium

Ch. Daulbayev; G. Mitchell; A. Zakhidov; F. Sultanov; Z. Mansurov

doi:10.18321/ectj690

Authors

Ch. Daulbayev Al-Farabi Kazakh National University, 71 al-Farabi Ave., 050040 Almaty, Kazakhstan; Institute of Combustion Problems, Bogenbay Batyr str. 172, 050012 Almaty, Kazakhstan
G. Mitchell Polytechnic Institute of Leiria, R. Gen. Norton de Matos, 2411-901 Leiria, Portugal
A. Zakhidov The University of Texas at Dallas, 800 W Campbell Rd, Richardson, TX 75080, USA
F. Sultanov Al-Farabi Kazakh National University, 71 al-Farabi Ave., 050040 Almaty, Kazakhstan; Institute of Combustion Problems, Bogenbay Batyr str. 172, 050012 Almaty, Kazakhstan
Z. Mansurov Institute of Combustion Problems, Bogenbay Batyr str. 172, 050012 Almaty, Kazakhstan

DOI:

https://doi.org/10.18321/ectj690

Abstract

In this paper, the possibility of obtaining a synthetic hydroxyapatite of calcium from a biological waste material is shown. The characteristics influencing the synthesis process are studied. Based on the results of the X-ray analysis and the obtained electron microscope images, it can be concluded that the synthesized HAP has a Ca/P ratio of 1.5 and with crystals with an average size of 2 microns. In work, experiments on obtaining biologically soluble films based on nanoscale polymer fibers and calcium hydroxyapatite were carried out. As a result, the main parameters of the process for the electroforming of nano-sized fibers with HAP are determined. The proposed method allows the laying of strictly directed nanofibers from a polymer with a diameter of 50 to 500 nm. The use of different types of electrodes makes it possible to vary the size of nanofibers. The characteristics such as solution viscosity, high voltage and optimum parameters were selected, which allowed obtaining films from biologically soluble polymer nanofibers and HAP. Also, experiments were conducted to introduce medicines into the film structure.

References

(1). Y. Wang, J. Mater. Sci. Technol. 32 (9) (2016) 801–809. Crossref DOI: https://doi.org/10.1016/j.jmst.2016.08.002

(2). B.A. Walter, S. Illien-Junger, P.R. Nasser, A.C. Hencht, J.C. Iatridis, J. Biomech. 47 (2014) 2095– 2101. Crossref DOI: https://doi.org/10.1016/j.jbiomech.2014.03.015

(3). A.J.R. Lasprilla, G.A.R. Martinez, B.H. Lunelli, A.L. Jardini, R. Maciel Filho, Biotechnol. Adv. 30 (1) (2012) 321–328. Crossref DOI: https://doi.org/10.1016/j.biotechadv.2011.06.019

(4). M. Saini, Y. Singh, P. Arora, V. Arora, K. Jain, World J Clin Cases 3 (1) (2015) 52–57. Crossref DOI: https://doi.org/10.12998/wjcc.v3.i1.52

(5). Y.X. Wang, J.L. Robertson, W.B. Spillman Jr., R.O. Claus, Pharm. Res. 21(8), 1362–1373 (2004) Crossref DOI: https://doi.org/10.1023/B:PHAM.0000036909.41843.18

(6). J.M. Rueger, W. Linhart, D. Sommerfeldt, Orthopäde 27 (1998) 89–95. Crossref DOI: https://doi.org/10.1007/PL00003483

(7). J. M. Rueger, Orthopäde 27 (1998) 72–79. Crossref DOI: https://doi.org/10.1007/PL00003481

(8). M. Epple, J. M. Rueger, Nachr. Chem. Tech. Lab. 47 (1999) 1405–1410. Crossref DOI: https://doi.org/10.1002/nadc.19990471210

(9). Ch.B. Daulbaev, T.P. Dmitriev, F.R. Sultanov, Z.A. Mansurov, E.T. Aliev, J. Eng. Phys. Thermophy. 90 (5) (2017) 1115–1118. Crossref DOI: https://doi.org/10.1007/s10891-017-1665-z

(10). Th. Leventouri, Biomaterials 27 (2006) 3339– 3342. Crossref DOI: https://doi.org/10.1016/j.biomaterials.2006.02.021

(11). P.C. Salgado, P.C. Sathler, H.C. Castro, G.G. Alves, A.M. Oliveira, R.C. Oliveira, M.D.C. Maia, C.R. Rodrigues, P.G. Coelh, A. Fuly, L.M. Cabral, J.M. Granjeiro, Journal of Biomaterials and Nanobiotechnology 2 (3) (2011) 318–328. Crossref DOI: https://doi.org/10.4236/jbnb.2011.23039

(12). A. Sobczak-Kupieca, D. Malinaa, R. Kijkowska, Z. Wzoreka, Digest Journal of Nanomaterials and Biostructures 7 (2012) 385– 391.

(13). M. Prodana, D. Bojin, D. Ionita Effect of hydroxyapatite on interface properties for alloy/ biofluid, The Scientific Bulletin of University politehnica of Bucharest. Series B, Chemistry and Materials Science 71 (4) (2009) 1454–2331.

(14). M. Lee and H.-Y. Kim, Langmuir 30 (5) (5) (2014) 1210–1214. Crossref DOI: https://doi.org/10.1021/la404704z

(15). Al-zubaidi Asaad Abdulhusseyn. Research of physical and chemical properties of metal-substituted nanocrystalline calcium-deficient hydroxyapatite. – 2014. – P. 12.